Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cadaverine Tartrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 7/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.34 |
| ▸ | HTR3B | O95264 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.34 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.34 |
| ▸ | OPA1 | O60313 | 1/20 | 0.34 |
| ▸ | EIF5B | O60841 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | HMOX2 | P30519 | 1/20 | 0.34 |
| ▸ | CD44 | P16070 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9681702 | 0.94 | MTNR1A (0.41) | MTNR1AMTNR1BHTR2AHTR2CHTR3E | |
| SCHEMBL7299112 | 0.78 | HTR3E (0.57) | MTNR1AMTNR1BHTR2AHTR2CHTR3E | |
| SCHEMBL9730191 | 0.77 | HTR3A (0.37) | MCL1HTR2AHTR2CHTR3EHTR3B | |
| SCHEMBL7332932 | 0.77 | MTNR1A (0.46) | MTNR1AMTNR1BHTR2AHTR2CHTR3E | |
| Hydrochloric Acid SCHEMBL9730401 | 0.77 | HTR3A (0.38) | HTR2AHTR2CHTR3EHTR3BHTR3A | |
| Hydrochloric Acid SCHEMBL9729932 | 0.76 | MCL1 (0.41) | MCL1HTR2AHTR2CCD44 | |
| Fumaric Acid SCHEMBL7298751 | 0.75 | HTR3E (0.52) | MTNR1AMTNR1BMCL1HTR2AHTR2C | |
| Maleic Acid SCHEMBL7298744 | 0.75 | HTR3E (0.52) | MTNR1AMTNR1BMCL1HTR2AHTR2C | |
| SCHEMBL8962729 | 0.74 | HTR3A (0.46) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| Maleic Acid SCHEMBL7273875 | 0.71 | HTR3E (0.42) | HTR3EHTR3BHTR3AHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0403261-A2 | Amide derivatives | GLAXO GROUP LIMITED (GB) | 1990-12-19 | — | — | EP | disclosed |