Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 12/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8963089 | 1.00 | KIF11 (0.46) | KIF11CYP11B2CYP11B1KDM1A | |
| SCHEMBL8962822 | 0.89 | KDM1A (0.47) | KIF11CYP11B2CYP11B1KDM1A | |
| SCHEMBL8962830 | 0.89 | KDM1A (0.47) | KIF11CYP11B2CYP11B1KDM1A | |
| SCHEMBL8962898 | 0.86 | KDM1A (0.43) | KIF11CYP11B2CYP11B1KDM1A | |
| SCHEMBL8963237 | 0.85 | P2RY14 (0.35) | CYP11B2CYP11B1KDM1A | |
| SCHEMBL8963228 | 0.85 | P2RY14 (0.35) | CYP11B2CYP11B1KDM1A | |
| SCHEMBL8962836 | 0.83 | JAK2 (0.35) | CYP11B2CYP11B1 | |
| SCHEMBL8962842 | 0.83 | JAK2 (0.35) | CYP11B2CYP11B1 | |
| SCHEMBL8962838 | 0.82 | SLC6A3 (0.39) | — | |
| SCHEMBL8962923 | 0.82 | KDM1A (0.37) | KIF11KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0559860-B1 | HALOVINYL-DERIVATIVES | HOFFMANN LA ROCHE (CH) | 1996-02-14 | — | — | EP | disclosed |
| US-5364556-A | Halovinyl-derivatives | HOFFMANN-LA ROCHE INC. (US) | 1994-11-15 | — | — | US | disclosed |
| WO-1993007234-A1 | HALOVINYL-DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1993-04-15 | — | — | WO | disclosed |