SCHEMBL8966403

SCHEMBL8966403

Cc1cccc(Nc2ccc(N=O)cc2C)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 1/20 0.47
AKR1C3 P42330 2/20 0.45
AKR1C2 P52895 2/20 0.45
PTGS1 P23219 2/20 0.44
PTGS2 P35354 2/20 0.44
MAPT P10636 3/20 0.42
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42
BRD4 O60885 1/20 0.41
KAT2B Q92831 1/20 0.41
BRD9 Q9H8M2 1/20 0.41
HTT P42858 3/20 0.40
HSD17B10 Q99714 2/20 0.40
CYP3A4 P08684 2/20 0.40
GAA P10253 2/20 0.40
NFKB1 P19838 1/20 0.40
ALDH1A1 P00352 1/20 0.40
TSHR P16473 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
CYP1A2 P05177 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1031031 0.85 ALDH1A1 (0.56) NPSR1AKR1C3AKR1C2MAPTMEN1
SCHEMBL5608725 0.81 NPSR1 (0.59) NPSR1AKR1C3AKR1C2PTGS1PTGS2
SCHEMBL9224929 0.80 HTT (0.63) NPSR1MAPTMEN1KMT2AHTT
SCHEMBL4974758 0.79 RAPGEF4 (0.50) MAPTMEN1KMT2AHTTHSD17B10
SCHEMBL44754 0.78 NPSR1 (0.55) NPSR1AKR1C3AKR1C2PTGS1PTGS2
SCHEMBL7001007 0.76 RAPGEF4 (0.53) NPSR1AKR1C3AKR1C2MAPTMEN1
SCHEMBL3690304 0.74 NPSR1 (0.64) NPSR1AKR1C3AKR1C2PTGS1PTGS2
SCHEMBL12019820 0.74 NPSR1 (0.59) NPSR1AKR1C3AKR1C2PTGS1PTGS2
SCHEMBL7003883 0.73 GAA (0.73) NPSR1AKR1C3AKR1C2MAPTMEN1
SCHEMBL26012913 0.72 ESR1 (0.37) NPSR1MAPTMEN1KMT2AHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0515151-B1 Dispersant, VI improver and antioxidant additive TEXACO DEVELOPMENT CORP (US) 1996-02-28 EP claimed
EP-0413429-B1 Dispersant anti-oxidant viscosity index improver and lubricating oil composition containing same TEXACO DEVELOPMENT CORP (US) 1994-01-12 EP claimed
EP-0515151-A1 Dispersant, VI improver and antioxidant additive TEXACO DEVELOPMENT CORPORATION (US) 1992-11-25 EP claimed
US-5160446-A Addition copolymer with unsaturated carboxy monomer, modified with alkylamine and an aromatic nitroso compound TEXACO INC. (US) 1992-11-03 US claimed
EP-0413429-A1 Dispersant anti-oxidant viscosity index improver and lubricating oil composition containing same TEXACO DEVELOPMENT CORPORATION (US) 1991-02-20 EP claimed
EP-0515151-B1 Dispersant, VI improver and antioxidant additive TEXACO DEVELOPMENT CORP (US) 1996-02-28 EP disclosed
EP-0413429-B1 Dispersant anti-oxidant viscosity index improver and lubricating oil composition containing same TEXACO DEVELOPMENT CORP (US) 1994-01-12 EP disclosed
EP-0515151-A1 Dispersant, VI improver and antioxidant additive TEXACO DEVELOPMENT CORPORATION (US) 1992-11-25 EP disclosed
US-5160446-A Addition copolymer with unsaturated carboxy monomer, modified with alkylamine and an aromatic nitroso compound TEXACO INC. (US) 1992-11-03 US disclosed
EP-0413429-A1 Dispersant anti-oxidant viscosity index improver and lubricating oil composition containing same TEXACO DEVELOPMENT CORPORATION (US) 1991-02-20 EP disclosed
US-4948524-A ETHYLENE COPOLYMER AND NITROSODIPHENYLAMINE TEXACO INC. (US) 1990-08-14 US disclosed