Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adipic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 3/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.41 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.41 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3877617 | 0.94 | PLA2G4B (0.45) | LTB4RPLA2G4BALDH1A1PTPN11KMT2A | |
| SCHEMBL5951005 | 0.86 | LTB4R (0.45) | LTB4RFFAR4FFAR1PLA2G4BALDH1A1 | |
| Isophthalic Acid SCHEMBL5951008 | 0.84 | FFAR4 (0.51) | LTB4RFFAR4FFAR1PTGER1PTGER4 | |
| SCHEMBL2185343 | 0.84 | KMT2A (0.48) | PLA2G4BALDH1A1KMT2ANR1H4 | |
| Isophthalic Acid SCHEMBL735784 | 0.83 | AKR1B1 (0.57) | LTB4RFFAR4FFAR1ALDH1A1KMT2A | |
| SCHEMBL5378258 | 0.82 | LTB4R (0.44) | LTB4RFFAR4FFAR1PLA2G4BPTGER1 | |
| SCHEMBL4596010 | 0.81 | ALDH1A1 (0.40) | FFAR4FFAR1PTGER1PTGER4PTGER3 | |
| SCHEMBL11104926 | 0.81 | LTB4R (0.43) | LTB4RFFAR4FFAR1PLA2G4BALDH1A1 | |
| SCHEMBL4944955 | 0.81 | PNLIP (0.50) | LTB4RPLA2G4BALDH1A1PTPN11KMT2A | |
| SCHEMBL5371926 | 0.81 | PNLIP (0.50) | LTB4RPLA2G4BALDH1A1PTPN11KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5532058-A | CARBODIIMIDE, AZIRIDINE | H. B. FULLER LICENSING & FINANCING, INC. (US) | 1996-07-02 | — | — | US | disclosed |
| US-5494960-A | HAVING POLYOL COMPONENTS WITH ACID FUNCTIONALITY; SHELF-LIFE STABILITY; TERTIARY AMINE STABILIZER | H.B. FULLER LICENSING & FINANCING, INC. (US) | 1996-02-27 | — | — | US | disclosed |