Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PABPC1 | P11940 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11537315 | 0.87 | PABPC1 (0.64) | PABPC1ALDH1A1TSHRKEAP1NFE2L2 | |
| SCHEMBL15453221 | 0.78 | PABPC1 (0.59) | PABPC1ALDH1A1TSHRKEAP1GAA | |
| SCHEMBL29506423 | 0.78 | PABPC1 (0.59) | PABPC1ALDH1A1TSHRKEAP1GAA | |
| SCHEMBL14384429 | 0.76 | IDO1 (0.57) | PABPC1 | |
| SCHEMBL14855633 | 0.76 | PABPC1 (0.53) | PABPC1ALDH1A1TSHRSLC40A1MEN1 | |
| SCHEMBL13611705 | 0.74 | PABPC1 (0.51) | PABPC1ALDH1A1TSHR | |
| SCHEMBL514306 | 0.74 | RAB9A (0.50) | PABPC1ALDH1A1TSHRHTTGAA | |
| SCHEMBL28858385 | 0.73 | PABPC1 (0.50) | PABPC1ALDH1A1TSHRHTTNPSR1 | |
| SCHEMBL6625263 | 0.72 | TDP1 (0.38) | ALDH1A1TSHRKEAP1NFE2L2SLC40A1 | |
| SCHEMBL2091838 | 0.72 | ALDH1A1 (0.46) | PABPC1ALDH1A1HTTSMN1; SMN2KDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5530138-A | A PYRROLIZINE DERIVATIVE; EFFECTIVE IN THE TREATMENT OF SENILE DEMENTIA | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1996-06-25 | — | — | US | disclosed |
| EP-0647642-A1 | 1-Azabicyclo(3.3.0)octane derivatives and their use | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1995-04-12 | — | — | EP | disclosed |