Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | NEK2 | P51955 | 1/20 | 0.46 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8967635 | 0.85 | SLC6A4 (0.43) | SIGMAR1OPRM1OPRL1HRH3KCNH2 | |
| SCHEMBL8967651 | 0.84 | SIGMAR1 (0.44) | SIGMAR1OPRM1OPRL1HRH3KCNH2 | |
| SCHEMBL8968120 | 0.84 | SLC6A3 (0.42) | SIGMAR1HRH3KCNH2KDM4E | |
| SCHEMBL8967617 | 0.82 | TUBB3 (0.38) | SIGMAR1HRH3IDO1KDM4E | |
| SCHEMBL8554443 | 0.79 | CTSB (0.43) | SIGMAR1KDM4E | |
| SCHEMBL8967541 | 0.76 | SIGMAR1 (0.37) | SIGMAR1OPRM1KCNH2KDM1AKDM4E | |
| SCHEMBL8967663 | 0.74 | SIGMAR1 (0.47) | SIGMAR1OPRM1KCNH2KDM1AKDM4E | |
| SCHEMBL8967681 | 0.73 | SIGMAR1 (0.40) | SIGMAR1 | |
| SCHEMBL8967724 | 0.71 | SIGMAR1 (0.38) | SIGMAR1HRH3KCNH2KDM4E | |
| SCHEMBL8967505 | 0.67 | SIGMAR1 (0.35) | SIGMAR1OPRM1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5530138-A | A PYRROLIZINE DERIVATIVE; EFFECTIVE IN THE TREATMENT OF SENILE DEMENTIA | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1996-06-25 | — | — | US | disclosed |
| EP-0647642-A1 | 1-Azabicyclo(3.3.0)octane derivatives and their use | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1995-04-12 | — | — | EP | disclosed |