Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT2B | Q92831 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8968053 | 0.99 | KAT2B (0.51) | KAT2BMAPTSMN1; SMN2NPC1RAB9A | |
| Fumaric Acid SCHEMBL8968115 | 0.91 | NPC1 (0.43) | KAT2BMAPTSMN1; SMN2NPC1RAB9A | |
| Maleic Acid SCHEMBL8967637 | 0.91 | NPC1 (0.43) | KAT2BMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL8555791 | 0.87 | MAPT (0.47) | KAT2BMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL8556050 | 0.85 | CTSB (0.43) | MAPTSMN1; SMN2ALDH1A1LMNAPKM | |
| SCHEMBL8967549 | 0.83 | MAPT (0.43) | MAPTSMN1; SMN2RAB9AALDH1A1LMNA | |
| SCHEMBL8967641 | 0.77 | SCN5A (0.42) | MAPTLMNAGAAIDO1 | |
| SCHEMBL16690122 | 0.77 | KAT2B (0.56) | KAT2BMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL8967906 | 0.76 | ICMT (0.46) | MAPTSMN1; SMN2RAB9AALDH1A1LMNA | |
| SCHEMBL8555094 | 0.76 | HRH3 (0.38) | MAPTSMN1; SMN2RAB9AALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5530138-A | A PYRROLIZINE DERIVATIVE; EFFECTIVE IN THE TREATMENT OF SENILE DEMENTIA | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1996-06-25 | — | — | US | claimed |
| EP-0647642-A1 | 1-Azabicyclo(3.3.0)octane derivatives and their use | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1995-04-12 | — | — | EP | claimed |
| US-5530138-A | A PYRROLIZINE DERIVATIVE; EFFECTIVE IN THE TREATMENT OF SENILE DEMENTIA | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1996-06-25 | — | — | US | disclosed |
| EP-0647642-A1 | 1-Azabicyclo(3.3.0)octane derivatives and their use | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1995-04-12 | — | — | EP | disclosed |