Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL8967637 | 1.00 | NPC1 (0.43) | NPC1RAB9AMAPTSMN1; SMN2KAT2B | |
| SCHEMBL8967939 | 0.91 | KAT2B (0.50) | NPC1RAB9AMAPTSMN1; SMN2KAT2B | |
| Hydrochloric Acid SCHEMBL8968053 | 0.90 | KAT2B (0.51) | NPC1RAB9AMAPTSMN1; SMN2KAT2B | |
| SCHEMBL8555791 | 0.79 | MAPT (0.47) | NPC1RAB9AMAPTSMN1; SMN2KAT2B | |
| SCHEMBL8556050 | 0.78 | CTSB (0.43) | MAPTSMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL8967549 | 0.76 | MAPT (0.43) | RAB9AMAPTSMN1; SMN2ALDH1A1POLB | |
| SCHEMBL16690122 | 0.70 | KAT2B (0.56) | NPC1RAB9AMAPTSMN1; SMN2KAT2B | |
| SCHEMBL8555094 | 0.69 | HRH3 (0.38) | RAB9AMAPTSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL8967645 | 0.69 | RAB9A (0.35) | RAB9AMAPTALDH1A1LMNAHTT | |
| SCHEMBL8968118 | 0.69 | RAB9A (0.35) | RAB9AMAPTALDH1A1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5530138-A | A PYRROLIZINE DERIVATIVE; EFFECTIVE IN THE TREATMENT OF SENILE DEMENTIA | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1996-06-25 | — | — | US | disclosed |