Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 2/20 | 0.34 |
| ▸ | AGXT | P21549 | 2/20 | 0.34 |
| ▸ | FADS1 | O60427 | 1/20 | 0.33 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | IKBKB | O14920 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8968519 | 0.98 | KEAP1 (0.39) | KEAP1ALDH1A1HDAC1HDAC3PSEN1 | |
| SCHEMBL8968019 | 0.80 | PSEN1 (0.39) | KEAP1ALDH1A1HDAC1HDAC3PSEN1 | |
| SCHEMBL190799 | 0.79 | TSHR (0.46) | ALDH1A1CYP3A4TSHRHSD17B10TDP1 | |
| SCHEMBL778121 | 0.79 | IDO1 (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL9538827 | 0.78 | NR3C2 (0.37) | — | |
| SCHEMBL8209451 | 0.74 | ALDH1A1 (0.46) | KEAP1ALDH1A1HDAC1IDO1AGXT | |
| SCHEMBL8967891 | 0.73 | ATM (0.46) | ALDH1A1IDO1SLC40A1CYP1A2TDP1 | |
| SCHEMBL5559482 | 0.73 | FDPS (0.42) | ALDH1A1CYP3A4CYP2C9TSHRHSD17B10 | |
| SCHEMBL27619224 | 0.73 | ADRA2B (0.41) | ALDH1A1CYP3A4TSHRHSD17B10TDP1 | |
| SCHEMBL14395630 | 0.73 | PSEN1 (0.39) | ALDH1A1PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5504095-A | Aminobenzosultam derivatives as lipoxygenase inhibitors | PFIZER INC. (US) | 1996-04-02 | — | — | US | disclosed |
| EP-0549666-B1 | NOVEL AMINOBENZOSULTAM DERIVATIVES AS LIPOXYGENASE INHIBITORS | PFIZER (US) | 1994-11-23 | — | — | EP | disclosed |
| EP-0549666-A1 | NOVEL AMINOBENZOSULTAM DERIVATIVES AS LIPOXYGENASE INHIBITORS. | PFIZER (US) | 1993-07-07 | — | — | EP | disclosed |
| WO-1992005164-A1 | NOVEL AMINOBENZOSULTAM DERIVATIVES AS LIPOXYGENASE INHIBITORS | PFIZER INC. (US) | 1992-04-02 | — | — | WO | disclosed |