Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.47 |
| ▸ | CLK2 | P49760 | 3/20 | 0.47 |
| ▸ | GSK3A | P49840 | 3/20 | 0.47 |
| ▸ | GSK3B | P49841 | 3/20 | 0.47 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.47 |
| ▸ | CDK1 | P06493 | 2/20 | 0.47 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | FLT4 | P35916 | 2/20 | 0.47 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.47 |
| ▸ | STK3 | Q13188 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8968165 | 0.85 | NPC1 (0.52) | RAB9ANPC1MAPTMEN1KMT2A | |
| SCHEMBL8968218 | 0.81 | CYP11B1 (0.54) | RAB9ANPC1KDM4EMAPTMEN1 | |
| SCHEMBL8968747 | 0.81 | CXCR1 (0.49) | RAB9AKDM4EPOLBMAPTMEN1 | |
| SCHEMBL8970501 | 0.80 | CXCR1 (0.45) | RAB9ANPC1KDM4EPOLBMAPT | |
| SCHEMBL8968160 | 0.75 | CXCR2 (0.65) | RAB9ANPC1KDM4EPOLBMAPT | |
| SCHEMBL5381046 | 0.71 | KDM4E (0.69) | RAB9ANPC1KDM4EPOLBMAPT | |
| SCHEMBL8968156 | 0.69 | GAA (0.49) | KDM4EPOLBGSK3BHTTHSD17B10 | |
| SCHEMBL8968199 | 0.69 | ABCC9 (0.45) | RAB9ANPC1MAPTMEN1KMT2A | |
| SCHEMBL8968203 | 0.69 | ABCC9 (0.45) | RAB9ANPC1MAPTMEN1KMT2A | |
| SCHEMBL3145830 | 0.69 | P2RY1 (0.71) | KDM4EMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0656350-A1 | Biaryl urea and related compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-06-07 | — | — | EP | claimed |
| US-5547966-A | Aryl urea and related compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-08-20 | — | — | US | disclosed |
| EP-0656350-A1 | Biaryl urea and related compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-06-07 | — | — | EP | disclosed |