Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR1 | P25024 | 2/20 | 0.45 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GRM5 | P41594 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.39 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8968218 | 0.87 | CYP11B1 (0.54) | CXCR1CXCR2MAPTMEN1KMT2A | |
| SCHEMBL8968747 | 0.86 | CXCR1 (0.49) | CXCR1CXCR2MAPTMEN1KMT2A | |
| SCHEMBL8968160 | 0.83 | CXCR2 (0.65) | CXCR1CXCR2MAPTMEN1KMT2A | |
| SCHEMBL8968172 | 0.80 | RAB9A (0.52) | MAPTMEN1KMT2AHTTRAB9A | |
| SCHEMBL8968165 | 0.76 | NPC1 (0.52) | CXCR1CXCR2MAPTMEN1KMT2A | |
| SCHEMBL8968156 | 0.72 | GAA (0.49) | CXCR1CXCR2ALDH1A1TSHRHTT | |
| SCHEMBL8970592 | 0.72 | CXCR1 (0.47) | CXCR1CXCR2MAPTMEN1KMT2A | |
| SCHEMBL8968199 | 0.71 | ABCC9 (0.45) | MAPTMEN1KMT2ALMNARAB9A | |
| SCHEMBL8968203 | 0.71 | ABCC9 (0.45) | MAPTMEN1KMT2ALMNARAB9A | |
| SCHEMBL3160036 | 0.70 | IDO1 (0.65) | P2RY1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0656350-A1 | Biaryl urea and related compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-06-07 | — | — | EP | claimed |
| US-5547966-A | Aryl urea and related compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-08-20 | — | — | US | disclosed |
| EP-0656350-A1 | Biaryl urea and related compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-06-07 | — | — | EP | disclosed |