Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | CFD | P00746 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.46 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8970479 | 0.87 | ALOX12 (0.68) | GAAPOLBTHRBALOX12SMN1; SMN2 | |
| SCHEMBL8968160 | 0.82 | CXCR2 (0.65) | GAAPOLBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL8970592 | 0.77 | CXCR1 (0.47) | GAAKDM4EALDH1A1HSD17B10CXCR1 | |
| SCHEMBL8970483 | 0.77 | EPHX2 (0.43) | GAAPOLBTHRBALOX12SMN1; SMN2 | |
| SCHEMBL7853764 | 0.77 | NAMPT (0.50) | CFDSMN1; SMN2CA12CA1CA2 | |
| SCHEMBL8968189 | 0.77 | ALDH1A1 (0.43) | GAATHRBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL18695146 | 0.76 | NAMPT (0.64) | POLBSMN1; SMN2HPGDHTTCA12 | |
| SCHEMBL7343971 | 0.75 | IMPDH2 (0.62) | SMN1; SMN2KDM4EALDH1A1GSK3BGLA | |
| SCHEMBL8968165 | 0.75 | NPC1 (0.52) | SMN1; SMN2MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL8968213 | 0.74 | CCR3 (0.47) | ALDH1A1CXCR1CXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0656350-A1 | Biaryl urea and related compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-06-07 | — | — | EP | claimed |
| JP-7188151-A | — | — | None | — | — | JP | disclosed |
| US-5547966-A | Aryl urea and related compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-08-20 | — | — | US | disclosed |
| JP-H07188151-A | BIARYL UREA AND RELATED COMPOUND | BRISTOL MYERS SQUIBB CO | 1995-07-25 | — | — | JP | disclosed |
| EP-0656350-A1 | Biaryl urea and related compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-06-07 | — | — | EP | disclosed |