Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XPO1 | O14980 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8969453 | 0.84 | ACHE (0.45) | HRH3ACHECHRNB2CHRNA4 | |
| SCHEMBL8969422 | 0.82 | HRH4 (0.34) | ACHEHRH4 | |
| SCHEMBL8970053 | 0.81 | ACHE (0.38) | ACHE | |
| SCHEMBL8968188 | 0.81 | ACHE (0.32) | ACHE | |
| SCHEMBL8969708 | 0.81 | ALDH1A1 (0.38) | HRH3CHRNB2CHRNA4PDE10AKCNH2 | |
| SCHEMBL8968293 | 0.73 | — | — | |
| SCHEMBL8968811 | 0.73 | LRRK2 (0.38) | HRH3CHRNB2CHRNA4KCNH2 | |
| SCHEMBL8968897 | 0.71 | BCHE (0.31) | ACHE | |
| SCHEMBL8969437 | 0.71 | BCHE (0.35) | ACHE | |
| SCHEMBL8968356 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5486512-A | LEARNING ENHANCEMENT | WARNER-LAMBERT COMPANY (US) | 1996-01-23 | — | — | US | disclosed |
| WO-1993003034-A1 | QUINAZOLINE DERIVATIVES AS ACETYLCHOLINESTERASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1993-02-18 | — | — | WO | disclosed |