SCHEMBL8969540

SCHEMBL8969540

Brc1ccc2c(c1)N=C1C3CC(C3)CN1C2

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
BCHE P06276 2/20 0.32
ACHE P22303 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8968877 0.89 PDE3B (0.33) BCHEACHE
SCHEMBL8968819 0.83 MAPK1 (0.34) BCHEACHE
SCHEMBL8969760 0.78 CTSD (0.34)
SCHEMBL8968722 0.71 ACHE (0.30) ACHE
SCHEMBL8968332 0.71 ACHE (0.30) ACHE
SCHEMBL8969474 0.68 CTSD (0.30)
SCHEMBL8968336 0.67
SCHEMBL8969988 0.66 CHRNB2 (0.35) ACHE
SCHEMBL8968413 0.65 ACHE (0.68) BCHEACHE
SCHEMBL6921297 0.64 ACHE (0.70) BCHEACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5486512-A LEARNING ENHANCEMENT WARNER-LAMBERT COMPANY (US) 1996-01-23 US disclosed
WO-1993003034-A1 QUINAZOLINE DERIVATIVES AS ACETYLCHOLINESTERASE INHIBITORS WARNER-LAMBERT COMPANY (US) 1993-02-18 WO disclosed