Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GNAI3 | P08754 | 2/20 | 0.33 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.33 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8972329 | 0.79 | GNAI3 (0.41) | GNAI3GNAO1GNAI1SMN1; SMN2 | |
| SCHEMBL10540257 | 0.75 | MAPT (0.53) | MAPTALDH1A1PKMPOLB | |
| SCHEMBL1842886 | 0.75 | SMN1; SMN2 (0.44) | SMN1; SMN2 | |
| SCHEMBL17877832 | 0.74 | ALDH1A1 (0.56) | MAPTALDH1A1PKMPOLBMAPK1 | |
| SCHEMBL9689240 | 0.74 | GNAO1 (0.38) | GNAI3GNAO1GNAI1KCNH2 | |
| SCHEMBL15925128 | 0.73 | DPP4 (0.41) | POLBKCNH2 | |
| SCHEMBL31719335 | 0.73 | MAPT (0.55) | MAPTALDH1A1PKMPOLBGNAI3 | |
| SCHEMBL8967209 | 0.73 | NCF1 (0.38) | GNAI3GNAO1GNAI1 | |
| SCHEMBL4500757 | 0.72 | GNAO1 (0.49) | MAPTALDH1A1PKMGNAI3GNAO1 | |
| SCHEMBL5672438 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0468457-B1 | Novel substituted piperidines and their use as inhibitors of cholesterol synthesis | MERRELL DOW PHARMA (US) | 1996-03-06 | — | — | EP | claimed |
| EP-0468457-A1 | Novel substituted piperidines and their use as inhibitors of cholesterol synthesis | MERRELL PHARMACEUTICALS INC. (US) | 1992-01-29 | — | — | EP | claimed |
| EP-0468457-B1 | Novel substituted piperidines and their use as inhibitors of cholesterol synthesis | MERRELL DOW PHARMA (US) | 1996-03-06 | — | — | EP | disclosed |
| EP-0468457-A1 | Novel substituted piperidines and their use as inhibitors of cholesterol synthesis | MERRELL PHARMACEUTICALS INC. (US) | 1992-01-29 | — | — | EP | disclosed |