Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 4/20 | 0.41 |
| ▸ | GNAO1 | P09471 | 4/20 | 0.41 |
| ▸ | GNAI1 | P63096 | 4/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8972223 | 0.79 | MAPT (0.44) | GNAI3GNAO1GNAI1SMN1; SMN2 | |
| SCHEMBL9689240 | 0.78 | GNAO1 (0.38) | GNAI3GNAO1GNAI1 | |
| SCHEMBL1842886 | 0.76 | SMN1; SMN2 (0.44) | SMN1; SMN2 | |
| SCHEMBL8972506 | 0.76 | GNAI3 (0.37) | GNAI3GNAO1GNAI1CHRM1SMN1; SMN2 | |
| SCHEMBL8971755 | 0.75 | DDAH1 (0.35) | GNAI3GNAO1GNAI1 | |
| Hydrochloric Acid SCHEMBL8972944 | 0.75 | GNAI3 (0.39) | GNAI3GNAO1GNAI1SMN1; SMN2 | |
| SCHEMBL15925128 | 0.75 | DPP4 (0.41) | — | |
| SCHEMBL30981065 | 0.74 | HTT (0.30) | — | |
| SCHEMBL8967209 | 0.74 | NCF1 (0.38) | GNAI3GNAO1GNAI1 | |
| SCHEMBL20082543 | 0.73 | GNAI3 (0.38) | GNAI3GNAO1GNAI1KEAP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0468457-B1 | Novel substituted piperidines and their use as inhibitors of cholesterol synthesis | MERRELL DOW PHARMA (US) | 1996-03-06 | — | — | EP | claimed |
| EP-0468457-A1 | Novel substituted piperidines and their use as inhibitors of cholesterol synthesis | MERRELL PHARMACEUTICALS INC. (US) | 1992-01-29 | — | — | EP | claimed |
| EP-0468457-B1 | Novel substituted piperidines and their use as inhibitors of cholesterol synthesis | MERRELL DOW PHARMA (US) | 1996-03-06 | — | — | EP | disclosed |
| EP-0468457-A1 | Novel substituted piperidines and their use as inhibitors of cholesterol synthesis | MERRELL PHARMACEUTICALS INC. (US) | 1992-01-29 | — | — | EP | disclosed |