Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 4/20 | 0.37 |
| ▸ | GNAO1 | P09471 | 4/20 | 0.37 |
| ▸ | GNAI1 | P63096 | 4/20 | 0.37 |
| ▸ | FPR3 | P25089 | 1/20 | 0.37 |
| ▸ | FPR2 | P25090 | 1/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | GBA1 | P04062 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8972944 | 0.99 | GNAI3 (0.39) | GNAI3GNAO1GNAI1FPR3FPR2 | |
| SCHEMBL8971745 | 0.81 | FPR3 (0.36) | GNAI3GNAO1GNAI1FPR3FPR2 | |
| Hydrochloric Acid SCHEMBL8972332 | 0.80 | RAD52 (0.37) | GNAI3GNAO1GNAI1FPR3FPR2 | |
| SCHEMBL8972354 | 0.79 | TP53 (0.45) | FPR3FPR2TP53SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8972193 | 0.78 | TP53 (0.44) | FPR3FPR2RAD52TP53SMN1; SMN2 | |
| SCHEMBL8972329 | 0.76 | GNAI3 (0.41) | GNAI3GNAO1GNAI1SMN1; SMN2CHRM1 | |
| SCHEMBL8764645 | 0.76 | HRH3 (0.48) | FPR3FPR2RAD52TP53SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8765083 | 0.74 | HRH3 (0.47) | FPR3FPR2RAD52TP53SMN1; SMN2 | |
| SCHEMBL8971755 | 0.74 | DDAH1 (0.35) | GNAI3GNAO1GNAI1OPRM1BCHE | |
| Hydrochloric Acid SCHEMBL8972341 | 0.73 | HRH3 (0.35) | GNAI3GNAO1GNAI1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0468457-B1 | Novel substituted piperidines and their use as inhibitors of cholesterol synthesis | MERRELL DOW PHARMA (US) | 1996-03-06 | — | — | EP | claimed |
| CN-1058394-A | Piperidines of new replacement and preparation method thereof and as the purposes of inhibitors of cholesterol synthesis | MERRELL DOW PHARMA (US) | 1992-02-05 | — | — | CN | claimed |
| EP-0468457-A1 | Novel substituted piperidines and their use as inhibitors of cholesterol synthesis | MERRELL PHARMACEUTICALS INC. (US) | 1992-01-29 | — | — | EP | claimed |
| EP-0468457-B1 | Novel substituted piperidines and their use as inhibitors of cholesterol synthesis | MERRELL DOW PHARMA (US) | 1996-03-06 | — | — | EP | disclosed |
| CN-1058394-A | Piperidines of new replacement and preparation method thereof and as the purposes of inhibitors of cholesterol synthesis | MERRELL DOW PHARMA (US) | 1992-02-05 | — | — | CN | disclosed |
| EP-0468457-A1 | Novel substituted piperidines and their use as inhibitors of cholesterol synthesis | MERRELL PHARMACEUTICALS INC. (US) | 1992-01-29 | — | — | EP | disclosed |