Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PI4KA | P42356 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CTSC | P53634 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8974661 | 0.86 | CA1 (0.45) | PTGS2CA12CA1CA2CA9 | |
| SCHEMBL9117303 | 0.83 | PTGS2 (0.45) | PTGS2LRRK2SLC22A12PIK3CDPIP5K1C | |
| SCHEMBL8973871 | 0.83 | RORC (0.41) | PTGS2PIK3CDPIP5K1CPIK3CBPI4KA | |
| SCHEMBL8974374 | 0.83 | PIK3CD (0.39) | PTGS2LRRK2PIK3CDPIP5K1CPIK3CB | |
| SCHEMBL8974603 | 0.82 | FAAH (0.41) | PTGS2PIK3CDPIP5K1CPIK3CBPI4KA | |
| SCHEMBL8974182 | 0.82 | PTGS2 (0.41) | PTGS2PIK3CDPIP5K1CPIK3CBPI4KA | |
| SCHEMBL9117711 | 0.81 | LRRK2 (0.41) | PTGS2LRRK2SLC22A12PIK3CDPIP5K1C | |
| SCHEMBL9118015 | 0.81 | LRRK2 (0.41) | PTGS2LRRK2SLC22A12PIK3CDPIP5K1C | |
| SCHEMBL8974143 | 0.80 | PTGS2 (0.63) | PTGS2CA12CA1CA2CA9 | |
| SCHEMBL8974709 | 0.78 | PTGS2 (0.42) | PTGS2SLC22A12PIK3CDPIP5K1CPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5576339-A | Pyridyl substituted cyclopentadienes for the treatment of inflamation | HUANG HORNG-CHIH (US) | 1996-11-19 | — | — | US | disclosed |
| US-5418254-A | Side effect reduction | G. D. SEARLE & CO. (US) | 1995-05-23 | — | — | US | disclosed |