Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.42 |
| ▸ | KIF11 | P52732 | 4/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PI4KA | P42356 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.36 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8975024 | 0.89 | PTGS2 (0.38) | PTGS2KIF11ALOX5APFEN1SLC22A12 | |
| SCHEMBL8974062 | 0.86 | KIF11 (0.45) | PTGS2KIF11ALOX5APFEN1 | |
| SCHEMBL9116580 | 0.86 | KIF11 (0.39) | PTGS2KIF11ALOX5APFEN1SLC22A12 | |
| SCHEMBL9119044 | 0.85 | KIF11 (0.38) | PTGS2KIF11ALOX5APFEN1POLB | |
| SCHEMBL8974182 | 0.85 | PTGS2 (0.41) | PTGS2PI4KBKCNH2PIK3CDPIP5K1C | |
| SCHEMBL9118890 | 0.83 | PTGS2 (0.48) | PTGS2KIF11ALOX5APFEN1SLC22A12 | |
| SCHEMBL8973871 | 0.83 | RORC (0.41) | PTGS2PI4KBPIK3CDPIP5K1CPIK3CB | |
| SCHEMBL8974374 | 0.83 | PIK3CD (0.39) | PTGS2ALOX5APPI4KBPIK3CDPIP5K1C | |
| SCHEMBL8973745 | 0.83 | POLB (0.39) | PTGS2KIF11ALOX5APFEN1SLC22A12 | |
| SCHEMBL8974150 | 0.83 | ALOX5AP (0.40) | PTGS2KIF11ALOX5APFEN1SLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5576339-A | Pyridyl substituted cyclopentadienes for the treatment of inflamation | HUANG HORNG-CHIH (US) | 1996-11-19 | — | — | US | disclosed |
| WO-1995030656-A1 | SUBSTITUTED CYCLOPENTADIENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-11-16 | — | — | WO | disclosed |
| US-5418254-A | Side effect reduction | G. D. SEARLE & CO. (US) | 1995-05-23 | — | — | US | disclosed |