Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | PI4KA | P42356 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 8/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.35 |
| ▸ | APLNR | P35414 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CCR6 | P51684 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | POLQ | O75417 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8973871 | 0.88 | RORC (0.41) | PIK3CDPIP5K1CPIK3CBPI4KAPIK3CG | |
| SCHEMBL8974603 | 0.87 | FAAH (0.41) | PIK3CDPIP5K1CPIK3CBPI4KAPIK3CG | |
| SCHEMBL8974182 | 0.87 | PTGS2 (0.41) | PIK3CDPIP5K1CPIK3CBPI4KAPIK3CG | |
| SCHEMBL8974334 | 0.87 | CA1 (0.44) | PTGS2KMT2AHSP90AA1CXCR5APLNR | |
| SCHEMBL8974709 | 0.83 | PTGS2 (0.42) | PIK3CDPIP5K1CPIK3CBPI4KAPIK3CG | |
| SCHEMBL8974335 | 0.83 | PTGS2 (0.42) | PIK3CDPIP5K1CPIK3CBPI4KAPIK3CG | |
| SCHEMBL17754086 | 0.82 | PIK3CD (0.49) | PIK3CDPIP5K1CPIK3CBPI4KAPIK3CG | |
| SCHEMBL9117193 | 0.81 | PTGS2 (0.49) | PIK3CDPIP5K1CPIK3CBPI4KAPIK3CG | |
| SCHEMBL9118447 | 0.79 | PTGS2 (0.44) | PIK3CDPIP5K1CPIK3CBPI4KAPIK3CG | |
| SCHEMBL9118885 | 0.79 | PTGS2 (0.44) | PIK3CDPIP5K1CPIK3CBPI4KAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5576339-A | Pyridyl substituted cyclopentadienes for the treatment of inflamation | HUANG HORNG-CHIH (US) | 1996-11-19 | — | — | US | disclosed |
| WO-1995030656-A1 | SUBSTITUTED CYCLOPENTADIENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-11-16 | — | — | WO | disclosed |
| US-5418254-A | Side effect reduction | G. D. SEARLE & CO. (US) | 1995-05-23 | — | — | US | disclosed |