Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 17/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | PI4KA | P42356 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8974374 | 0.87 | PIK3CD (0.39) | PTGS2PTGS1PIK3CDPIP5K1CPIK3CB | |
| SCHEMBL8973871 | 0.87 | RORC (0.41) | PTGS2PTGS1PIK3CDPIP5K1CPIK3CB | |
| SCHEMBL8973749 | 0.85 | CA1 (0.44) | PTGS2PTGS1HTR2AKCNH2 | |
| SCHEMBL8974603 | 0.85 | FAAH (0.41) | PTGS2PTGS1PIK3CDPIP5K1CPIK3CB | |
| SCHEMBL8974709 | 0.85 | PTGS2 (0.42) | PTGS2PIK3CDPIP5K1CPIK3CBPI4KA | |
| SCHEMBL9117872 | 0.84 | HTR2A (0.45) | PTGS2PTGS1CDK9PIK3CDPIP5K1C | |
| SCHEMBL9117440 | 0.82 | PTGS2 (0.66) | PTGS2PTGS1CDK9PIK3CDPIP5K1C | |
| SCHEMBL8974335 | 0.82 | PTGS2 (0.42) | PTGS2PIK3CDPIP5K1CPIK3CBPI4KA | |
| SCHEMBL8973732 | 0.81 | PTGS2 (0.40) | PTGS2PTGS1CDK9PIK3CDPIP5K1C | |
| SCHEMBL8974381 | 0.81 | PTGS2 (0.47) | PTGS2PTGS1CDK9PIK3CDPIP5K1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995030656-A1 | SUBSTITUTED CYCLOPENTADIENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-11-16 | — | — | WO | claimed |
| US-5576339-A | Pyridyl substituted cyclopentadienes for the treatment of inflamation | HUANG HORNG-CHIH (US) | 1996-11-19 | — | — | US | disclosed |
| US-5418254-A | Side effect reduction | G. D. SEARLE & CO. (US) | 1995-05-23 | — | — | US | disclosed |