SCHEMBL8977289

SCHEMBL8977289

O=c1[nH]nnn1-c1cc(C(F)(F)F)ccc1Cl

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 3/20 0.46
CRHBP P24387 1/20 0.46
CRHR2 Q13324 1/20 0.46
CDK4 P11802 1/20 0.45
CCND1 P24385 1/20 0.45
HSP90AA1 P07900 3/20 0.40
TRAP1 Q12931 3/20 0.40
HSP90B1 P14625 1/20 0.40
KMT2A Q03164 3/20 0.39
ALDH1A1 P00352 2/20 0.39
L3MBTL1 Q9Y468 2/20 0.39
MEN1 O00255 2/20 0.39
TSHR P16473 2/20 0.39
ATM Q13315 1/20 0.39
HTT P42858 2/20 0.38
MAPT P10636 2/20 0.38
KDM4E B2RXH2 1/20 0.38
GAA P10253 1/20 0.38
ADRA1B P35368 1/20 0.38
LMNA P02545 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8599859 0.89 MARS1 (0.39) NPSR1CRHBPCRHR2CDK4CCND1
SCHEMBL5906327 0.84 HSP90AA1 (0.39) NPSR1HSP90AA1KMT2AALDH1A1MEN1
SCHEMBL8977258 0.82 MAPT (0.44) CDK4CCND1L3MBTL1HTTMAPT
SCHEMBL2161285 0.75 ATM (0.47) NPSR1ALDH1A1L3MBTL1ATMHTT
SCHEMBL9730328 0.75 HCAR1 (0.38)
SCHEMBL5906416 0.74 NOTUM (0.53) CYP1A2
SCHEMBL8601024 0.74 FFAR1 (0.47) KMT2AL3MBTL1MEN1
SCHEMBL2161237 0.74 HTT (0.58) KMT2AALDH1A1L3MBTL1MEN1HTT
SCHEMBL5905865 0.73 MGLL (0.43) CDK4CCND1HSP90AA1ALDH1A1MAPT
SCHEMBL8599863 0.73 GAA (0.49) NPSR1KMT2AALDH1A1L3MBTL1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0708097-A1 Herbicidally active tetrazolinones NIHON BAYER AGROCHEM K.K. (JP) 1996-04-24 EP disclosed