Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.57 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | PTGES | O14684 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | BRD4 | O60885 | 3/20 | 0.41 |
| ▸ | EP300 | Q09472 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8523784 | 0.80 | PTGS1 (0.61) | PTGS2CYP19A1PTGS1MEN1PTGES | |
| SCHEMBL8942521 | 0.80 | CYP19A1 (0.82) | PTGS2CYP19A1PTGS1MEN1PTGES | |
| SCHEMBL8091326 | 0.76 | CYP19A1 (0.67) | PTGS2CYP19A1PTGS1MEN1PTGES | |
| SCHEMBL3241465 | 0.76 | BRD4 (0.54) | PTGS1MEN1ALDH1A1MAPTTSHR | |
| SCHEMBL8979019 | 0.76 | PTGS2 (0.49) | PTGS2CYP19A1PTGS1MEN1PTGES | |
| SCHEMBL8979118 | 0.75 | CYP19A1 (0.65) | PTGS2CYP19A1PTGS1MEN1PTGES | |
| Propylamine SCHEMBL8942567 | 0.75 | RORC (0.48) | PTGS2CYP19A1PTGS1MEN1PTGES | |
| SCHEMBL18301651 | 0.74 | P2RX4 (0.50) | PTGS2CYP19A1PTGS1MEN1PTGES | |
| SCHEMBL9233767 | 0.74 | PTGS2 (0.47) | PTGS2CYP19A1PTGS1MEN1PTGES | |
| SCHEMBL8942579 | 0.74 | MEN1 (0.47) | PTGS2CYP19A1PTGS1MEN1PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0641774-B1 | 5-AMINOSULFONANILIDE COMPOUND | TAISHO PHARMACEUTICAL CO LTD (JP) | 1996-05-08 | — | — | EP | disclosed |
| EP-0641774-A1 | 5-AMINOSULFONANILIDE COMPOUND | TAISHO PHARMACEUTICAL CO. LTD (JP) | 1995-03-08 | — | — | EP | disclosed |
| US-5374764-A | Antiinflammatory agens, antipyretics, analgesics and antiallergens | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 1994-12-20 | — | — | US | disclosed |