Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | CTSV | O60911 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8980608 | 0.87 | L3MBTL1 (0.55) | MAOBMAOAL3MBTL1RAB9AMAPT | |
| SCHEMBL8980558 | 0.84 | PTGER1 (0.50) | MAOBRAB9ACTSVCTSLMAPT | |
| SCHEMBL8980703 | 0.80 | ALDH1A1 (0.62) | L3MBTL1RAB9AMAPTNPSR1SMN1; SMN2 | |
| SCHEMBL7761823 | 0.78 | MEN1 (0.49) | MAOBMAOAPLA2G4BRAB9ACTSV | |
| SCHEMBL8759753 | 0.74 | MAOB (0.56) | MAOBMAOAL3MBTL1RAB9AMAPT | |
| SCHEMBL3093865 | 0.74 | CTSV (0.58) | L3MBTL1RAB9ACTSVCTSLMEN1 | |
| SCHEMBL15716510 | 0.73 | ALDH1A1 (0.58) | CTSVCTSLMEN1KMT2ALMNA | |
| SCHEMBL6564473 | 0.73 | CYP19A1 (0.56) | RAB9ACTSVCTSLMAPTMEN1 | |
| SCHEMBL8980579 | 0.72 | TSHR (0.53) | MAOBL3MBTL1NPSR1MEN1KMT2A | |
| SCHEMBL6568015 | 0.72 | MAPT (0.48) | MAOBMAOARAB9AMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1132508-A | Piperazine derivatives | REORDATI IND CHIMICA E FARMACE (CH) | 1996-10-02 | — | — | CN | disclosed |
| EP-0711288-A1 | PIPERAZINE DERIVATIVES AS ALPHA 1A-ADRENERGIC RECEPTOR ANTAGONISTS | RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.p.a. (IT) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995004049-A1 | PIPERAZINE DERIVATIVES AS α1A-ADRENERGIC RECEPTOR ANTAGONISTS | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1995-02-09 | — | — | WO | disclosed |