SCHEMBL8980703

SCHEMBL8980703

CCC(=O)c1cccc(C(=O)O)c1OCc1ccc(C(=O)c2ccccc2)cc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.62
HTT P42858 4/20 0.62
SMN1; SMN2 Q16637 3/20 0.62
RAB9A P51151 3/20 0.62
MAPT P10636 2/20 0.62
GAA P10253 1/20 0.62
HPGD P15428 4/20 0.55
NPSR1 Q6W5P4 2/20 0.55
L3MBTL1 Q9Y468 1/20 0.51
ATM Q13315 1/20 0.51
SRD5A2 P31213 2/20 0.49
CYP2C9 P11712 1/20 0.48
CYP2C19 P33261 1/20 0.48
PPARG P37231 1/20 0.46
NPC1 O15118 1/20 0.44
RXRA P19793 3/20 0.43
RXRB P28702 2/20 0.43
RXRG P48443 1/20 0.43
ELANE P08246 1/20 0.43
NR4A2 P43354 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8980558 0.89 PTGER1 (0.50) ALDH1A1HTTSMN1; SMN2RAB9AMAPT
SCHEMBL8980925 0.88 ALDH1A1 (0.60) ALDH1A1HTTSMN1; SMN2RAB9AMAPT
SCHEMBL8980593 0.80 MAOB (0.49) ALDH1A1SMN1; SMN2RAB9AMAPTNPSR1
SCHEMBL15716510 0.79 ALDH1A1 (0.58) ALDH1A1HPGDSRD5A2NR4A2PTGER1
SCHEMBL8980579 0.76 TSHR (0.53) ALDH1A1HTTSMN1; SMN2HPGDNPSR1
SCHEMBL5313068 0.76 NPC1 (0.50) ALDH1A1HTTSMN1; SMN2RAB9AMAPT
SCHEMBL10805271 0.75 SLC6A3 (0.45) ALDH1A1HTTSMN1; SMN2MAPTGAA
SCHEMBL8980650 0.75 MAOB (0.54) ALDH1A1SMN1; SMN2MAPTHPGDL3MBTL1
SCHEMBL6905551 0.75 LMNA (0.55) ALDH1A1SMN1; SMN2RAB9AMAPTGAA
SCHEMBL27894245 0.75 PTGER1 (0.47) ALDH1A1HTTSMN1; SMN2RAB9AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1132508-A Piperazine derivatives REORDATI IND CHIMICA E FARMACE (CH) 1996-10-02 CN disclosed
EP-0711288-A1 PIPERAZINE DERIVATIVES AS ALPHA 1A-ADRENERGIC RECEPTOR ANTAGONISTS RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.p.a. (IT) 1996-05-15 EP disclosed
WO-1995004049-A1 PIPERAZINE DERIVATIVES AS α1A-ADRENERGIC RECEPTOR ANTAGONISTS RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) 1995-02-09 WO disclosed