Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 7/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | MIF | P14174 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9302379 | 0.92 | MAOB (0.36) | PKMTSHRMAOBPRMT5WDR77 | |
| SCHEMBL9304584 | 0.91 | MAOB (0.37) | PKMTSHRMAOBPRMT5WDR77 | |
| SCHEMBL9303640 | 0.84 | KMT2A (0.36) | TSHRALDH1A1 | |
| SCHEMBL9302635 | 0.83 | MAOB (0.36) | PKMMAOBALDH1A1 | |
| SCHEMBL9304354 | 0.82 | ALDH1A1 (0.43) | ALDH1A1 | |
| SCHEMBL8980560 | 0.81 | PKM (0.36) | PKMTSHRMAOBPRMT5WDR77 | |
| Sinitrodil SCHEMBL503115 | 0.79 | TSHR (0.34) | PKMTSHRMAOBPRMT5WDR77 | |
| Sinitrodil SCHEMBL31066546 | 0.79 | TSHR (0.34) | PKMTSHRMAOBPRMT5WDR77 | |
| SCHEMBL8638816 | 0.79 | ALDH1A1 (0.41) | TSHRPRMT5WDR77ALDH1A1 | |
| SCHEMBL9809787 | 0.79 | MEN1 (0.35) | MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711286-A1 | BENZOXAZINONES AND BENZOTHIAZINONES ENDOWED WITH THERAPEUTIC ACTIVITY | ITALFARMACO S.p.A. (IT) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995004048-A1 | BENZOXAZINONES AND BENZOTHIAZINONES ENDOWED WITH THERAPEUTIC ACTIVITY | ITALFARMACO S.P.A. (IT) | 1995-02-09 | — | — | WO | disclosed |
| US-5308844-A | ANTIDEPRESSANT, ANXIOLYTIC AGENT, ANALGESIC, HYPOTENSIVE AGENT | PIERRE FABRE MEDICAMENT (FR) | 1994-05-03 | — | — | US | disclosed |