Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9681186 | 0.94 | CNR1 (0.44) | MAPTCYP3A4CYP2C9CYP2C19GABRA1 | |
| SCHEMBL8984886 | 0.89 | MAPT (0.49) | MAPTPTPN1CYP3A4CYP2C19HDAC1 | |
| SCHEMBL8984878 | 0.88 | PPARG (0.49) | MAPTALDH1A1KMT2A | |
| SCHEMBL8984881 | 0.85 | CYP1A2 (0.49) | MAPTCYP2C19ALDH1A1HDAC1HDAC2 | |
| SCHEMBL9680956 | 0.83 | RXRA (0.48) | MAPTCYP3A4CYP2C9CYP2C19HDAC1 | |
| SCHEMBL9680935 | 0.83 | RXRA (0.53) | MAPTCYP3A4CYP2C9CYP2C19HDAC1 | |
| SCHEMBL9358192 | 0.81 | RXRA (0.54) | CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL9358203 | 0.81 | RXRA (0.54) | CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL9680898 | 0.81 | MAPT (0.47) | MAPTPTPN1CYP3A4CYP2C19GABRA1 | |
| SCHEMBL9362113 | 0.81 | GABRA1 (0.53) | CYP3A4CYP2C9CYP2C19GABRA1GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0473308-B1 | Aldose reductase inhibitor | ASAHI CHEMICAL IND (JP) | 1996-05-22 | — | — | EP | disclosed |
| US-5155259-A | High stability; prevention and therapy of diabetic complications | TOYO JOZO KABUSHIKI KAISHA (JP) | 1992-10-13 | — | — | US | disclosed |
| EP-0473308-A1 | Aldose reductase inhibitor | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1992-03-04 | — | — | EP | disclosed |