Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 4/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | UBE2N | P61088 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8985514 | 0.85 | PTGS2 (0.42) | PTGS1L3MBTL1NPC1UBE2NTDP1 | |
| SCHEMBL8985459 | 0.84 | CYP1A2 (0.37) | PTGS1GSK3BL3MBTL1NPC1UBE2N | |
| SCHEMBL8985226 | 0.81 | MAPK14 (0.47) | PTGS1L3MBTL1NPC1UBE2NTDP1 | |
| SCHEMBL8985463 | 0.79 | PTGS1 (0.35) | PTGS1L3MBTL1NPC1UBE2NTDP1 | |
| SCHEMBL8985294 | 0.78 | PTGS1 (0.40) | PTGS1L3MBTL1NPC1UBE2NTDP1 | |
| SCHEMBL8985532 | 0.76 | MAPK14 (0.53) | PTGS1L3MBTL1NPC1UBE2NTDP1 | |
| SCHEMBL8985333 | 0.75 | GSK3B (0.42) | PTGS1GSK3BNPC1PTGS2ALDH1A1 | |
| SCHEMBL222551 | 0.75 | ALDH1A1 (0.52) | NPC1ALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8985491 | 0.70 | PTGS2 (0.43) | PTGS1L3MBTL1NPC1UBE2NTDP1 | |
| SCHEMBL8985319 | 0.69 | PTGS2 (0.34) | PTGS1NPC1PTGS2ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5571810-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, COLLAGEN DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-11-05 | — | — | US | disclosed |
| EP-0593761-A1 | NEW THIOPHENE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-27 | — | — | EP | disclosed |
| WO-1991019708-A1 | NEW THIOPHENE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-12-26 | — | — | WO | disclosed |