Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | EP300 | Q09472 | 4/20 | 0.33 |
| ▸ | APP | P05067 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8985252 | 0.85 | MAPK14 (0.44) | MAPK14OPRD1PTGS1PTGS2EP300 | |
| SCHEMBL8985373 | 0.83 | OPRD1 (0.61) | MAPK14OPRD1PTGS1PTGS2EP300 | |
| SCHEMBL8985296 | 0.80 | PTGS1 (0.44) | PTGS1PTGS2APPKDM4EHPGD | |
| SCHEMBL8985506 | 0.80 | APP (0.33) | APP | |
| SCHEMBL8985255 | 0.79 | MAPK14 (0.45) | MAPK14OPRD1PTGS1PTGS2 | |
| SCHEMBL8985415 | 0.77 | PTGS2 (0.50) | MAPK14OPRD1PTGS1PTGS2KDM4E | |
| SCHEMBL8985497 | 0.77 | APP (0.35) | MAPK14PTGS2APP | |
| SCHEMBL7619448 | 0.75 | PTGS2 (0.68) | MAPK14OPRD1PTGS1PTGS2KDM4E | |
| SCHEMBL8985516 | 0.71 | MAPK14 (0.83) | MAPK14OPRD1PTGS1PTGS2KDM4E | |
| SCHEMBL15824911 | 0.70 | TSHR (0.42) | APPMAPTHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5571810-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, COLLAGEN DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-11-05 | — | — | US | disclosed |
| EP-0593761-A1 | NEW THIOPHENE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-27 | — | — | EP | disclosed |
| WO-1991019708-A1 | NEW THIOPHENE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-12-26 | — | — | WO | disclosed |