Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | NPY1R | P25929 | 1/20 | 0.41 |
| ▸ | NPY2R | P49146 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8990066 | 0.87 | RAB9A (0.42) | HTTSMN1; SMN2LMNATSHRNPSR1 | |
| SCHEMBL9285258 | 0.77 | ALDH1A1 (0.59) | HTTSMN1; SMN2LMNATSHRNPSR1 | |
| SCHEMBL7478340 | 0.71 | ALDH1A1 (0.40) | HTTSMN1; SMN2LMNATSHRNPSR1 | |
| SCHEMBL10869503 | 0.68 | LMNA (0.52) | HTTSMN1; SMN2LMNANPSR1ALDH1A1 | |
| SCHEMBL15228172 | 0.68 | RAB9A (0.49) | HTTSMN1; SMN2LMNANPSR1ALDH1A1 | |
| SCHEMBL13543523 | 0.67 | RAB9A (0.54) | HTTSMN1; SMN2LMNAHPGDL3MBTL1 | |
| SCHEMBL14974686 | 0.67 | RAB9A (0.48) | SMN1; SMN2LMNACYP1A2CYP2D6MAPK1 | |
| SCHEMBL15228167 | 0.65 | TSHR (0.57) | HTTSMN1; SMN2LMNATSHRALDH1A1 | |
| SCHEMBL5712364 | 0.65 | ALDH1A1 (0.59) | HTTSMN1; SMN2LMNATSHRALDH1A1 | |
| SCHEMBL7485545 | 0.64 | ALDH1A1 (0.45) | HTTSMN1; SMN2LMNATSHRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5552426-A | NERVOUS SYSTEM DISORDERS USING IMIDAZOLE DERIVITIVES | ELI LILLY AND COMPANY (US) | 1996-09-03 | — | — | US | disclosed |