Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.43 |
| ▸ | HPGD | P15428 | 8/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8990670 | 0.82 | ALDH1A1 (0.43) | RAB9ANPC1RECQLALDH1A1HSD17B10 | |
| SCHEMBL8990955 | 0.76 | RAB9A (0.43) | RAB9ANPC1RECQLALDH1A1HSD17B10 | |
| SCHEMBL8990667 | 0.71 | HPGD (0.44) | RAB9ANPC1RECQLALDH1A1HSD17B10 | |
| SCHEMBL8990569 | 0.67 | RAB9A (0.48) | RAB9ANPC1RECQLALDH1A1HSD17B10 | |
| SCHEMBL28295524 | 0.66 | TARBP2 (0.62) | ALDH1A1HSD17B10KDM4EHPGDGAA | |
| SCHEMBL27545042 | 0.62 | RAB9A (0.51) | RAB9ANPC1RECQLALDH1A1HSD17B10 | |
| SCHEMBL3436254 | 0.62 | L3MBTL1 (0.58) | RAB9ANPC1ALDH1A1HSD17B10KDM4E | |
| SCHEMBL7458131 | 0.60 | RXRA (0.49) | ALDH1A1KDM4EHPGDMAPTTSHR | |
| SCHEMBL27955900 | 0.60 | FFAR1 (0.45) | RECQLALDH1A1HSD17B10KDM4EHPGD | |
| SCHEMBL14721145 | 0.60 | FFAR1 (0.45) | RECQLALDH1A1HSD17B10KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5500428-A | Furyl-substituted purines and adenosine antagonists | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1996-03-19 | — | — | US | disclosed |
| US-5300509-A | Adenosine antagonists for treating cardiovascular disorders, vasodilation | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-04-05 | — | — | US | disclosed |
| EP-0544445-A2 | Furyl-substituted purines, oxazolopyrimidines and pteridines as adenosine antagonists | ZENECA LIMITED (GB) | 1993-06-02 | — | — | EP | disclosed |