Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 8/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | HSPA8 | P11142 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.32 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.31 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.31 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.31 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.31 |
| ▸ | GRK6 | P43250 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | GLA | P06280 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8991164 | 0.87 | LRRK2 (0.40) | LRRK2DYRK1AHSPA8CDK5CDK5R1 | |
| SCHEMBL7697510 | 0.86 | LRRK2 (0.58) | LRRK2DYRK1AHSPA8CDK5CDK5R1 | |
| SCHEMBL8991180 | 0.84 | LRRK2 (0.43) | LRRK2KDM4EALDH1A1GLAGAA | |
| SCHEMBL8991004 | 0.77 | YTHDC1 (0.31) | YTHDC1EGFRSRC | |
| SCHEMBL8991158 | 0.77 | KMT2A (0.49) | LRRK2KDM4EALDH1A1GLAGAA | |
| SCHEMBL8991163 | 0.77 | YTHDC1 (0.31) | YTHDC1EGFRSRC | |
| SCHEMBL8990982 | 0.76 | GAA (0.42) | LRRK2KDM4EALDH1A1GLAGAA | |
| SCHEMBL8991316 | 0.76 | ALDH1A1 (0.55) | LRRK2KDM4EALDH1A1GLAGAA | |
| SCHEMBL8991012 | 0.74 | XDH (0.33) | — | |
| SCHEMBL8991176 | 0.74 | XDH (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5543413-A | VIRAL ACTIVITY AGAINST HUMAN CYTOMEGALOVIRUS AND HERPES SIMPLEX VIRUS | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 1996-08-06 | — | — | US | disclosed |