SCHEMBL8992328

SCHEMBL8992328

C=CC[SiH](C)c1ccccc1

nearest known ligand 0.34

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.33
TSHR P16473 2/20 0.33
MAPT P10636 1/20 0.31
CYP2C19 P33261 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8770165 0.78 ALDH1A1 (0.33) ALDH1A1TSHRMAPT
SCHEMBL3850181 0.77 ALDH1A1 (0.33) ALDH1A1TSHRCYP2C19
SCHEMBL860549 0.76 CYP2C19 (0.36) ALDH1A1TSHRMAPTCYP2C19
SCHEMBL216362 0.76 ALDH1A1 (0.36) ALDH1A1TSHRCYP2C19
SCHEMBL9637491 0.76 MAOB (0.31)
SCHEMBL8769557 0.75 ALDH1A1 (0.34) ALDH1A1TSHR
Fluoride SCHEMBL27912992 0.74 CYP2C19 (0.35) ALDH1A1TSHRCYP2C19
SCHEMBL1493083 0.73 ALDH1A1 (0.33) ALDH1A1TSHRCYP2C19
SCHEMBL9267683 0.73 CYP1A2 (0.35) ALDH1A1TSHRCYP2C19
SCHEMBL9256810 0.73 ALDH1A1 (0.33) ALDH1A1TSHRCYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5516871-A Diphenylsiloxane oligomers functionalized at both terminals and methods for the preparation thereof DOW CORNING ASIA, LTD. (JP) 1996-05-14 US claimed
US-5502229-A ENDCAPPING DOW CORNING ASIA, LTD. (JP) 1996-03-26 US claimed
US-5516871-A Diphenylsiloxane oligomers functionalized at both terminals and methods for the preparation thereof DOW CORNING ASIA, LTD. (JP) 1996-05-14 US disclosed
US-5502229-A ENDCAPPING DOW CORNING ASIA, LTD. (JP) 1996-03-26 US disclosed