Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALM1 | P0DP23 | 5/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.37 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8992958 | 0.87 | LTA4H (0.59) | PKMLTA4HFLT3ALDH1A1CA2 | |
| SCHEMBL27327790 | 0.86 | CYP19A1 (0.61) | CALM1PKMFGFR3CYP19A1FLT3 | |
| SCHEMBL8992947 | 0.85 | LTA4H (0.49) | LTA4H | |
| SCHEMBL1046247 | 0.85 | ALDH1A1 (0.50) | CALM1PKMFGFR3CYP19A1FLT3 | |
| SCHEMBL31739223 | 0.82 | MAOA (0.51) | CALM1LTA4HCYP19A1AKR1B1RAB9A | |
| SCHEMBL9203057 | 0.81 | ALDH1A1 (0.43) | CALM1PKMFGFR3CYP19A1FLT3 | |
| 3-Methoxyphenylacetonitrile SCHEMBL103029 | 0.81 | PKM (0.61) | CALM1PKMLTA4HFLT3ALDH1A1 | |
| 3-Methoxyphenylacetonitrile SCHEMBL29253102 | 0.79 | PKM (0.59) | PKMLTA4HFLT3ALDH1A1CA2 | |
| 3-Methoxyphenylacetonitrile SCHEMBL27728444 | 0.79 | PKM (0.59) | CALM1PKMLTA4HFLT3ALDH1A1 | |
| SCHEMBL5252553 | 0.78 | ALDH1A1 (0.65) | CALM1LTA4HCYP19A1AKR1B1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516777-A | PROSTATE CANCER THERAPY | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-14 | — | — | US | disclosed |
| US-5409928-A | Prostate diseases, alopecia | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-04-25 | — | — | US | disclosed |
| EP-0594149-A2 | Condensed pyrazole derivatives, method of manufacturing the same, and androgen inhibitor | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-27 | — | — | EP | disclosed |