Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | AGXT | P21549 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | FABP4 | P15090 | 1/20 | 0.37 |
| ▸ | ALPL | P05186 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8993128 | 0.90 | DHFR (0.46) | DHFRNPC1RAB9AALDH1A1TACR1 | |
| SCHEMBL8632096 | 0.88 | ALDH1A1 (0.50) | DHFRNPC1RAB9AALDH1A1TACR1 | |
| SCHEMBL8993256 | 0.87 | KDM4C (0.41) | DHFRTACR1KDM4C | |
| SCHEMBL8992804 | 0.81 | DHFR (0.39) | DHFRNPC1RAB9ATACR1CNR2 | |
| SCHEMBL8992789 | 0.78 | TACR1 (0.40) | NPC1RAB9ATACR1TDP1LMNA | |
| SCHEMBL93016 | 0.77 | SMN1; SMN2 (0.47) | NPC1RAB9AALDH1A1TDP1GAA | |
| SCHEMBL8321396 | 0.75 | NPC1 (0.50) | NPC1RAB9ATACR1IDO1AGXT | |
| SCHEMBL5423197 | 0.74 | NPC1 (0.52) | DHFRNPC1RAB9AALDH1A1TACR1 | |
| SCHEMBL8711253 | 0.74 | ALDH1A1 (0.62) | NPC1ALDH1A1LMNAHPGDPOLB | |
| SCHEMBL8992945 | 0.74 | ICAM1 (0.38) | NPC1RAB9ATACR1KDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516777-A | PROSTATE CANCER THERAPY | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-14 | — | — | US | disclosed |
| US-5409928-A | Prostate diseases, alopecia | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-04-25 | — | — | US | disclosed |
| EP-0594149-A2 | Condensed pyrazole derivatives, method of manufacturing the same, and androgen inhibitor | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-27 | — | — | EP | disclosed |