Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10711525 | 0.83 | IDO1 (0.46) | TSHRIDO1TAAR1CHRM2CHRM1 | |
| SCHEMBL198463 | 0.82 | IDO1 (0.52) | TSHRIDO1TAAR1CHRM2CHRM1 | |
| SCHEMBL621779 | 0.80 | HTR1A (0.58) | LTA4HTSHRIDO1TAAR1HTR1A | |
| SCHEMBL3999884 | 0.80 | DRD2 (0.53) | TSHRHTR1AALDH1A1GAAMAPT | |
| SCHEMBL8993391 | 0.79 | CNR2 (0.44) | NPC1THRBRAB9ATSHRHTR7 | |
| SCHEMBL7282070 | 0.79 | LTA4H (0.62) | LTA4HTSHRIDO1TAAR1CHRM2 | |
| SCHEMBL3153666 | 0.79 | KMT2A (0.56) | LTA4HIDO1TAAR1HTR1AADRA1D | |
| SCHEMBL1682187 | 0.79 | LTA4H (0.52) | NPC1RAB9ALTA4HIDO1TAAR1 | |
| SCHEMBL8993373 | 0.79 | LTA4H (0.43) | NPC1RAB9ALTA4HTSHRTAAR1 | |
| SCHEMBL9470803 | 0.77 | LTA4H (0.51) | LTA4HIDO1TAAR1HTR1AADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516777-A | PROSTATE CANCER THERAPY | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-14 | — | — | US | disclosed |
| US-5409928-A | Prostate diseases, alopecia | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-04-25 | — | — | US | disclosed |
| EP-0594149-A2 | Condensed pyrazole derivatives, method of manufacturing the same, and androgen inhibitor | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-27 | — | — | EP | disclosed |
| EP-0149077-B1 | (3-ARYL-2,3-DIHYDROBENZOFURAN-3-YL)ALKYLAMINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1988-09-21 | — | — | EP | disclosed |
| US-4602035-A | Antidepressant (3-aryl-2,3-dihydrobenzofuran-3-yl)alkylamines | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1986-07-22 | — | — | US | disclosed |
| EP-0149077-A1 | (3-Aryl-2,3-dihydrobenzofuran-3-yl)alkylamines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1985-07-24 | — | — | EP | disclosed |