Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
| ▸ | GPR52 | Q9Y2T5 | 2/20 | 0.44 |
| ▸ | BRS3 | P32247 | 1/20 | 0.43 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | PRKCI | P41743 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.41 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.41 |
| ▸ | IDH1 | O75874 | 2/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.40 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8992946 | 0.90 | MAPKAPK2 (0.46) | LTA4HMAPKAPK2MEN1KMT2ACHEK2 | |
| SCHEMBL8993010 | 0.87 | GPR52 (0.47) | LTA4HMTNR1AMTNR1BGPR52PRKCZ | |
| SCHEMBL8992766 | 0.85 | LTA4H (0.46) | LTA4HBRS3KMT2ANR3C2 | |
| SCHEMBL8993194 | 0.84 | PLA2G2A (0.44) | LTA4HBRS3MEN1KMT2A | |
| SCHEMBL8992951 | 0.72 | LTA4H (0.57) | LTA4HMTNR1AMTNR1BBRS3DHFR | |
| SCHEMBL8992780 | 0.72 | BRS3 (0.54) | BRS3EGLN1ALKBH1 | |
| SCHEMBL9218801 | 0.71 | NPC1 (0.54) | MEN1KMT2ACHEK2RIPK2 | |
| SCHEMBL8992815 | 0.71 | LTA4H (0.43) | LTA4HMTNR1AMTNR1BGPR52BRS3 | |
| SCHEMBL8992950 | 0.71 | LTA4H (0.43) | LTA4HMTNR1AMTNR1BBRS3MEN1 | |
| SCHEMBL8136072 | 0.70 | TAAR1 (0.61) | LTA4HMTNR1AMTNR1BDHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516777-A | PROSTATE CANCER THERAPY | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-14 | — | — | US | disclosed |
| US-5409928-A | Prostate diseases, alopecia | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-04-25 | — | — | US | disclosed |
| EP-0594149-A2 | Condensed pyrazole derivatives, method of manufacturing the same, and androgen inhibitor | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-27 | — | — | EP | disclosed |