Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.46 |
| ▸ | GRM2 | Q14416 | 6/20 | 0.41 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 2/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8993005 | 0.90 | LTA4H (0.49) | MAPKAPK2GRM2KMT2AMEN1CHEK2 | |
| SCHEMBL8993194 | 0.81 | PLA2G2A (0.44) | NPC1RAB9AKMT2AMEN1LTA4H | |
| SCHEMBL8992766 | 0.79 | LTA4H (0.46) | NPC1RAB9AKMT2ALTA4HALDH1A1 | |
| SCHEMBL8993010 | 0.77 | GPR52 (0.47) | MAPKAPK2NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL9218801 | 0.71 | NPC1 (0.54) | NPC1RAB9AKMT2AMAPTMEN1 | |
| SCHEMBL8993148 | 0.69 | KMT2A (0.41) | CALM1NPC1RAB9AKMT2AMAPT | |
| SCHEMBL8993248 | 0.67 | CALM1 (0.59) | CALM1LTA4HCYP19A1ALDH1A1 | |
| SCHEMBL28598360 | 0.65 | RXRA (0.62) | CALM1NPC1RAB9ALTA4HALDH1A1 | |
| SCHEMBL19039706 | 0.64 | CYP19A1 (0.67) | CALM1LTA4HCYP19A1ALDH1A1GAA | |
| SCHEMBL5252553 | 0.63 | ALDH1A1 (0.65) | CALM1LTA4HCYP19A1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516777-A | PROSTATE CANCER THERAPY | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-14 | — | — | US | disclosed |
| US-5409928-A | Prostate diseases, alopecia | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-04-25 | — | — | US | disclosed |
| EP-0594149-A2 | Condensed pyrazole derivatives, method of manufacturing the same, and androgen inhibitor | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-27 | — | — | EP | disclosed |