Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 12/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | BRS3 | P32247 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8992934 | 0.87 | GPR119 (0.47) | GPR119 | |
| SCHEMBL8992815 | 0.86 | LTA4H (0.43) | GPR119LTA4HFYNKDRBRS3 | |
| SCHEMBL8992922 | 0.84 | GPR119 (0.43) | GPR119LTA4HFYNKDRBRS3 | |
| SCHEMBL11776811 | 0.83 | TLR8 (0.51) | GPR119KDRTLR8 | |
| SCHEMBL8993229 | 0.80 | BRS3 (0.52) | GPR119FYNKDRBRS3 | |
| SCHEMBL8992991 | 0.77 | NPC1 (0.57) | GPR119KDRBRS3 | |
| SCHEMBL8993106 | 0.75 | DHFR (0.40) | GPR119KDRTLR8 | |
| SCHEMBL8992903 | 0.73 | FYN (0.40) | GPR119FYNKDR | |
| SCHEMBL8992904 | 0.72 | GPR119 (0.39) | GPR119FYNKDR | |
| SCHEMBL13990623 | 0.71 | NPC1 (0.54) | KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516777-A | PROSTATE CANCER THERAPY | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-14 | — | — | US | disclosed |
| US-5409928-A | Prostate diseases, alopecia | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-04-25 | — | — | US | disclosed |
| EP-0594149-A2 | Condensed pyrazole derivatives, method of manufacturing the same, and androgen inhibitor | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-27 | — | — | EP | disclosed |