Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 4/20 | 0.40 |
| ▸ | FYN | P06241 | 4/20 | 0.39 |
| ▸ | BRS3 | P32247 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | FES | P07332 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | LYN | P07948 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8992965 | 0.88 | GPR119 (0.41) | GPR119KDRHCAR2POLBALDH1A1 | |
| SCHEMBL8992904 | 0.87 | GPR119 (0.39) | GPR119KDRFYNHCAR2EGFR | |
| SCHEMBL8992955 | 0.87 | NPC1 (0.43) | GPR119FYNALDH1A1HPGDMEN1 | |
| SCHEMBL8993403 | 0.86 | RAB9A (0.44) | GPR119LTA4HFYNBRS3SRC | |
| SCHEMBL8992950 | 0.86 | LTA4H (0.43) | LTA4HFYNBRS3HCAR2ABL1 | |
| SCHEMBL8993247 | 0.84 | GPR119 (0.49) | GPR119LTA4HKDRFYNBRS3 | |
| SCHEMBL8993183 | 0.84 | FYN (0.40) | GPR119KDRFYNHCAR2EGFR | |
| SCHEMBL9221803 | 0.83 | ALDH1A1 (0.44) | KDRSRCPOLBALDH1A1HPGD | |
| SCHEMBL8993290 | 0.81 | GPR119 (0.41) | GPR119LTA4HBRS3POLBALDH1A1 | |
| SCHEMBL8993213 | 0.81 | RAB9A (0.46) | GPR119KDRPOLBALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516777-A | PROSTATE CANCER THERAPY | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-14 | — | — | US | disclosed |
| US-5409928-A | Prostate diseases, alopecia | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-04-25 | — | — | US | disclosed |
| EP-0594149-A2 | Condensed pyrazole derivatives, method of manufacturing the same, and androgen inhibitor | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-27 | — | — | EP | disclosed |