Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.38 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.37 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8992903 | 0.90 | FYN (0.40) | DHFRHCAR2KDRFGFR1FGFR4 | |
| SCHEMBL8992815 | 0.87 | LTA4H (0.43) | DHFRHCAR2KDRGPR119GPR52 | |
| SCHEMBL8993032 | 0.86 | DHFR (0.40) | DHFRHCAR2KDRFGFR1FGFR4 | |
| SCHEMBL8993019 | 0.83 | BRS3 (0.47) | HCAR2GPR52 | |
| SCHEMBL8992845 | 0.77 | FYN (0.40) | DHFRHCAR2KDRFGFR1FGFR4 | |
| SCHEMBL8993247 | 0.75 | GPR119 (0.49) | KDRGPR119TLR8 | |
| SCHEMBL13990623 | 0.75 | NPC1 (0.54) | HCAR2KDRPIM1MEN1KMT2A | |
| SCHEMBL8992904 | 0.74 | GPR119 (0.39) | HCAR2KDRGPR119CYP1A2ENPP1 | |
| SCHEMBL8993010 | 0.74 | GPR52 (0.47) | DHFRGPR52IDH1MEN1KMT2A | |
| SCHEMBL8993244 | 0.73 | BRS3 (0.47) | HCAR2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516777-A | PROSTATE CANCER THERAPY | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-14 | — | — | US | disclosed |
| US-5409928-A | Prostate diseases, alopecia | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-04-25 | — | — | US | disclosed |
| EP-0594149-A2 | Condensed pyrazole derivatives, method of manufacturing the same, and androgen inhibitor | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-27 | — | — | EP | disclosed |