Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | AGXT | P21549 | 2/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 2/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4947525 | 0.89 | CYP19A1 (0.53) | LMNAMAPTCYP3A4IDO1CYP19A1 | |
| SCHEMBL5870558 | 0.86 | IDO1 (0.50) | LMNAALDH1A1MAPTIDO1CYP19A1 | |
| SCHEMBL8206287 | 0.86 | LMNA (0.46) | LMNASMN1; SMN2ALDH1A1MAPTPGR | |
| SCHEMBL11207479 | 0.83 | LMNA (0.44) | LMNASMN1; SMN2ALDH1A1MAPTPGR | |
| SCHEMBL776918 | 0.82 | ALDH1A1 (0.50) | ALDH1A1IDO1AGXTCYP19A1BCHE | |
| SCHEMBL5697490 | 0.81 | GAA (0.55) | LMNASMN1; SMN2ALDH1A1MAPTBCHE | |
| SCHEMBL8993165 | 0.81 | PKM (0.52) | LMNAALDH1A1IDO1AGXTBCHE | |
| SCHEMBL2890 | 0.81 | CA9 (0.53) | LMNASMN1; SMN2ALDH1A1MAPTCYP3A4 | |
| SCHEMBL7403082 | 0.81 | ALDH1A1 (0.57) | LMNAALDH1A1MAPTCYP3A4IDO1 | |
| SCHEMBL9430144 | 0.80 | ALDH1A1 (0.45) | LMNASMN1; SMN2ALDH1A1BCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516777-A | PROSTATE CANCER THERAPY | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-14 | — | — | US | disclosed |
| US-5409928-A | Prostate diseases, alopecia | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-04-25 | — | — | US | disclosed |
| EP-0594149-A2 | Condensed pyrazole derivatives, method of manufacturing the same, and androgen inhibitor | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-27 | — | — | EP | disclosed |