Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | PGR | P06401 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | CFTR | P13569 | 5/20 | 0.42 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL899464 | 1.00 | LMNA (0.43) | LMNAPGRALDH1A1KDM4EGAA | |
| SCHEMBL899540 | 0.90 | AR (0.42) | LMNAALDH1A1KMT2ACFTRCA2 | |
| SCHEMBL899539 | 0.90 | AR (0.42) | LMNAALDH1A1KMT2ACFTRCA2 | |
| SCHEMBL899436 | 0.85 | PDE4D (0.39) | LMNAALDH1A1KDM4EGAAHPGD | |
| SCHEMBL899437 | 0.85 | PDE4D (0.39) | LMNAALDH1A1KDM4EGAAHPGD | |
| SCHEMBL899582 | 0.77 | SMN1; SMN2 (0.42) | LMNAALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL899584 | 0.77 | SMN1; SMN2 (0.42) | LMNAALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL898781 | 0.76 | ROCK2 (0.41) | LMNASMN1; SMN2POLBMAPK1RAB9A | |
| SCHEMBL899307 | 0.74 | MAPT (0.46) | LMNAALDH1A1HPGDSMN1; SMN2MAPK1 | |
| SCHEMBL899306 | 0.74 | MAPT (0.46) | LMNAALDH1A1HPGDSMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012040754-A2 | NOVEL THIAZOLAMINE DERIVATES AS DIFFERENTIATION ACCELERATORS | TECHNISCHE UNIVERSITÄT WIEN (AT) | 2012-04-05 | — | — | WO | disclosed |
| WO-2012040754-A2 | NOVEL THIAZOLAMINE DERIVATES AS DIFFERENTIATION ACCELERATORS | TECHNISCHE UNIVERSITÄT WIEN (AT) | 2012-04-05 | — | — | WO | disclosed |