Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.33 |
| ▸ | CCNC | P24863 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | CTSA | P10619 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL898780 | 1.00 | ROCK2 (0.41) | ROCK2ROCK1EGLN1PDE4DPDE7A | |
| SCHEMBL899436 | 0.81 | PDE4D (0.39) | PDE4DPDE7AMAPK1NPSR1LMNA | |
| SCHEMBL899437 | 0.81 | PDE4D (0.39) | PDE4DPDE7AMAPK1NPSR1LMNA | |
| SCHEMBL899584 | 0.81 | SMN1; SMN2 (0.42) | PDE4DPDE7AMAPK1NPSR1LMNA | |
| SCHEMBL899582 | 0.81 | SMN1; SMN2 (0.42) | PDE4DPDE7AMAPK1NPSR1LMNA | |
| SCHEMBL898805 | 0.78 | GRM5 (0.34) | PDE4DPDE7AMAPK1NPSR1GRM5 | |
| SCHEMBL898806 | 0.78 | GRM5 (0.34) | PDE4DPDE7AMAPK1NPSR1GRM5 | |
| SCHEMBL899463 | 0.76 | LMNA (0.43) | MAPK1LMNAPOLBSMN1; SMN2RAB9A | |
| SCHEMBL899307 | 0.73 | MAPT (0.46) | MAPK1NPSR1LMNASMN1; SMN2NPC1 | |
| SCHEMBL899306 | 0.73 | MAPT (0.46) | MAPK1NPSR1LMNASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012040754-A2 | NOVEL THIAZOLAMINE DERIVATES AS DIFFERENTIATION ACCELERATORS | TECHNISCHE UNIVERSITÄT WIEN (AT) | 2012-04-05 | — | — | WO | claimed |
| WO-2012040754-A2 | NOVEL THIAZOLAMINE DERIVATES AS DIFFERENTIATION ACCELERATORS | TECHNISCHE UNIVERSITÄT WIEN (AT) | 2012-04-05 | — | — | WO | disclosed |