Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ALPI | P09923 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8995002 | 0.88 | LMNA (0.46) | LTB4RLMNASMN1; SMN2NPC1NFKB1 | |
| SCHEMBL8995047 | 0.85 | LTB4R (0.47) | LTB4RLTB4R2GAAGPR119L3MBTL1 | |
| SCHEMBL8594096 | 0.82 | PPARG (0.37) | LTB4RLMNASMN1; SMN2NPC1NFKB1 | |
| SCHEMBL8995088 | 0.81 | LTB4R (0.49) | LTB4RLMNASMN1; SMN2NPC1NFKB1 | |
| SCHEMBL8592790 | 0.80 | NPC1 (0.34) | LTB4RLMNASMN1; SMN2NPC1NFKB1 | |
| SCHEMBL8994854 | 0.80 | LTB4R (0.62) | LTB4RLMNALTB4R2L3MBTL1 | |
| SCHEMBL8994894 | 0.75 | LTB4R (0.67) | LTB4RLTB4R2THRB | |
| SCHEMBL8592505 | 0.74 | NFKB1 (0.39) | LTB4RLMNASMN1; SMN2NPC1NFKB1 | |
| SCHEMBL8589592 | 0.73 | PPARG (0.38) | LTB4RLMNASMN1; SMN2NPC1NFKB1 | |
| SCHEMBL8995034 | 0.72 | LTB4R (0.64) | LTB4RLTB4R2THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5488160-A | LEUKOTRIENE B4 RECEPTOR ANTAGONIST AS ANTIINFLAMMATORY AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-01-30 | — | — | US | claimed |
| US-5488160-A | LEUKOTRIENE B4 RECEPTOR ANTAGONIST AS ANTIINFLAMMATORY AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-01-30 | — | — | US | disclosed |