SCHEMBL8995982

SCHEMBL8995982

C=C1CC(=O)N(c2ccc(Nc3ccc(C)cc3)cc2)C1=O

nearest known ligand 0.50

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.49
KMT2A Q03164 4/20 0.49
GAA P10253 2/20 0.49
TLR9 Q9NR96 1/20 0.49
MAPT P10636 3/20 0.46
SMN1; SMN2 Q16637 1/20 0.43
ALDH1A1 P00352 3/20 0.43
APP P05067 1/20 0.42
F2 P00734 1/20 0.42
ELANE P08246 1/20 0.42
CTSG P08311 1/20 0.42
CMA1 P23946 1/20 0.42
CTRC Q99895 1/20 0.42
LMNA P02545 1/20 0.41
HPGD P15428 2/20 0.40
POLB P06746 1/20 0.40
MGLL Q99685 1/20 0.40
HTT P42858 1/20 0.39
HSP90AA1 P07900 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2983688 0.91 GAA (0.57) MEN1KMT2AGAATLR9MAPT
SCHEMBL8995947 0.86 HSP90AA1 (0.54) MEN1KMT2AGAATLR9MAPT
SCHEMBL8995929 0.84 MAPT (0.50) MEN1KMT2AGAAMAPTSMN1; SMN2
SCHEMBL237914 0.82 GAA (0.44) MEN1KMT2AGAATLR9MAPT
SCHEMBL8995936 0.81 MEN1 (0.55) MEN1KMT2AGAAMAPTSMN1; SMN2
SCHEMBL27398038 0.77 MAPT (0.54) MEN1KMT2AGAATLR9MAPT
SCHEMBL4894350 0.74 MEN1 (0.54) MEN1KMT2AMAPTSMN1; SMN2ALDH1A1
SCHEMBL26659455 0.74 ALDH1A1 (0.40) MEN1KMT2AGAATLR9MAPT
SCHEMBL4443303 0.74 MGLL (0.56) MEN1KMT2AALDH1A1LMNAHPGD
SCHEMBL225820 0.73 GAA (0.58) MEN1KMT2AGAATLR9ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0570825-B1 Tire sidewall composition containing silica having low PH GOODYEAR TIRE & RUBBER (US) 1996-08-07 EP disclosed
EP-0475215-B1 Carboxylic acid esters with thio groups GOODYEAR TIRE & RUBBER (US) 1994-10-19 EP disclosed
EP-0570825-A1 Tire sidewall composition containing silica having low PH THE GOODYEAR TIRE & RUBBER COMPANY (US) 1993-11-24 EP disclosed
US-5244028-A Natural rubber or polybutadiene, silica, antidegradation agent, carbon black THE GOODYEAR TIRE & RUBBER COMPANY (US) 1993-09-14 US disclosed
US-5216049-A A phenolic or amine stabilizer and an organothioalkylene styrene bound to a polymer; aging resistance; rubbers THE GOODYEAR TIRE & RUBBER COMPANY (US) 1993-06-01 US disclosed
EP-0475215-A1 Carboxylic acid esters with thio groups THE GOODYEAR TIRE & RUBBER COMPANY (US) 1992-03-18 EP disclosed
US-5069819-A SYNERGISTS FOR CONVENTIONAL PHENOLIC AND AMINE ANTIOXIDANTS THE GOODYEAR TIRE & RUBBER COMPANY (US) 1991-12-03 US disclosed