Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 2/20 | 0.41 |
| ▸ | MMP1 | P03956 | 3/20 | 0.40 |
| ▸ | MMP7 | P09237 | 3/20 | 0.40 |
| ▸ | MMP12 | P39900 | 3/20 | 0.40 |
| ▸ | MMP13 | P45452 | 3/20 | 0.40 |
| ▸ | ACE | P12821 | 2/20 | 0.40 |
| ▸ | CASP1 | P29466 | 2/20 | 0.39 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.39 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.37 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5592398 | 0.89 | MMP2 (0.43) | MMP3MMP1MMP7MMP12MMP13 | |
| SCHEMBL2807339 | 0.80 | MMP13 (0.55) | MMP1MMP7MMP12MMP13ACE | |
| Hydroxyamine SCHEMBL7645294 | 0.77 | MMP2 (0.52) | MMP3MMP12LTB4R2F10 | |
| SCHEMBL7027498 | 0.73 | MMP3 (0.47) | MMP3CA1CA2F10 | |
| SCHEMBL27348452 | 0.73 | SOAT1 (0.40) | MMP12CASP1SOAT1ALDH1A1F10 | |
| SCHEMBL7029504 | 0.70 | F10 (0.45) | MMP3MMP13CA1CA2F10 | |
| SCHEMBL10516417 | 0.70 | MMP13 (0.40) | MMP1MMP7MMP12MMP13ACE | |
| SCHEMBL2703944 | 0.69 | ALOX5AP (0.46) | SOAT1KDM4EALDH1A1PTPN1 | |
| SCHEMBL27907686 | 0.68 | ALOX5AP (0.47) | MMP1MMP12MMP13CASP1CA1 | |
| SCHEMBL27182979 | 0.68 | MMP13 (0.57) | MMP3MMP1MMP7MMP12MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5512681-A | HORMONE INHIBITORS FOR TREATMENT OF HYPERTENSION OR CONGESTIVE HEART FAILURE | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1996-04-30 | — | — | US | claimed |
| US-5512681-A | HORMONE INHIBITORS FOR TREATMENT OF HYPERTENSION OR CONGESTIVE HEART FAILURE | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1996-04-30 | — | — | US | disclosed |