Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.31 |
| ▸ | THRA | P10827 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8997218 | 0.83 | PTGS1 (0.33) | SIRT2SIRT1ALOX15CYP4A11CA12 | |
| SCHEMBL8997212 | 0.82 | CYP4A11 (0.42) | ALOX15CYP4A11CA1CA2CYP4F2 | |
| SCHEMBL8997437 | 0.70 | DHFR (0.44) | SIRT2SIRT1CYP4A11CA12CA1 | |
| SCHEMBL9827531 | 0.68 | THRA (0.43) | SIRT2SIRT1CYP4A11CA12CA1 | |
| SCHEMBL8569916 | 0.68 | MTR (0.41) | SIRT2SIRT1 | |
| SCHEMBL9617435 | 0.68 | DHFR (0.40) | SIRT2SIRT1PTGS1 | |
| SCHEMBL9446058 | 0.68 | CYP4A11 (0.41) | SIRT2SIRT1CYP4A11CA12CA1 | |
| SCHEMBL31688879 | 0.67 | CYP4A11 (0.49) | SIRT2SIRT1CYP4A11CA12CA1 | |
| SCHEMBL9446055 | 0.67 | CYP4A11 (0.40) | SIRT2SIRT1CYP4A11CA12CA1 | |
| SCHEMBL6209198 | 0.66 | CYP4A11 (0.50) | SIRT2SIRT1CYP4A11CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0334636-B1 | Pyrrolopyrimidine derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1996-10-23 | — | — | EP | disclosed |
| US-5539113-A | ANTITUMOR AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-07-23 | — | — | US | disclosed |
| US-5296600-A | Antitumor agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-03-22 | — | — | US | disclosed |
| US-5106974-A | Antitumor and -carcinogenic agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-04-21 | — | — | US | disclosed |
| US-4997838-A | Antitumor agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1991-03-05 | — | — | US | disclosed |
| EP-0334636-A2 | Pyrrolopyrimidine derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1989-09-27 | — | — | EP | disclosed |