Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.37 |
| ▸ | SOAT1 | P35610 | 6/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | EIF4A1 | P60842 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | TUBB | P07437 | 1/20 | 0.34 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.34 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.34 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9000550 | 0.85 | SORT1 (0.40) | SOAT1KMT2ALMNATSHR | |
| SCHEMBL9000766 | 0.83 | SOAT1 (0.38) | SOAT1MEN1KMT2AHPGDCYP1A2 | |
| SCHEMBL9001013 | 0.81 | MAPT (0.42) | MAPK1SOAT1MEN1KMT2A | |
| SCHEMBL9000583 | 0.77 | KDM1A (0.37) | SOAT1HPGDLMNA | |
| SCHEMBL9000816 | 0.77 | SOAT1 (0.37) | SOAT1MEN1KMT2AHPGDLMNA | |
| SCHEMBL9000920 | 0.76 | MAPK1 (0.37) | RAB9AMAPK1SOAT1 | |
| SCHEMBL9000603 | 0.76 | SOAT1 (0.35) | RAB9AMAPK1SOAT1MEN1KMT2A | |
| SCHEMBL8322248 | 0.75 | SOAT1 (0.49) | SOAT1MEN1KMT2ATSHR | |
| SCHEMBL9000915 | 0.74 | SOAT1 (0.44) | RAB9AMAPK1SOAT1 | |
| SCHEMBL9000515 | 0.73 | SOAT1 (0.36) | SOAT1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583147-A | INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL O-TRANSFERASE; ANTIHYPERCHOLESTEROLEMIC AND/OR ANTIATHEROSCLEROTIC AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-10 | — | — | US | disclosed |