Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOAT1 | P35610 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CD38 | P28907 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9000419 | 0.76 | SOAT1 (0.41) | SOAT1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL9000550 | 0.76 | SORT1 (0.40) | SOAT1TSHRKMT2A | |
| SCHEMBL9000743 | 0.74 | SOAT1 (0.38) | SOAT1RAB9AMEN1KMT2A | |
| SCHEMBL9000766 | 0.74 | SOAT1 (0.38) | SOAT1MEN1CYP1A2HPGDKMT2A | |
| SCHEMBL9001010 | 0.72 | SOAT1 (0.43) | SOAT1ALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL9000644 | 0.71 | PLK1 (0.38) | SOAT1TSHRNPC1RAB9AMEN1 | |
| SCHEMBL9000682 | 0.69 | SOAT1 (0.40) | SOAT1ALDH1A1KDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL4492754 | 0.68 | SOAT1 (0.47) | SOAT1ALDH1A1KDM4EMEN1CYP1A2 | |
| SCHEMBL32667998 | 0.68 | CYP1A2 (0.50) | SOAT1ALDH1A1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL8343161 | 0.68 | SOAT1 (0.45) | SOAT1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583147-A | INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL O-TRANSFERASE; ANTIHYPERCHOLESTEROLEMIC AND/OR ANTIATHEROSCLEROTIC AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-10 | — | — | US | disclosed |